Stage IV Widespread involvement of one or more sites other than lymph nodes , with or without associated lymph node involvement, or isolated extralymphatic organ involvement with distant lymph node involvement.
Each stage may be further sub-divided into A or B according to the presence or absence of general symptoms. "A" means the absence of "B" symptoms, which include any of: unexplained fevers over 38°C (100.4°F), drenching night sweats or the unexplained loss of at least 10 percent of body weight.